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KMID : 0545120140240070921
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Journal of Microbiology and Biotechnology
2014 Volume.24 No. 7 p.921 ~ p.924
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In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses
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Lee Dong-Hun
Youn Ha-Na
Park Jae-Keun
Kang Byung-Hwa
Kang Jae-Hoon
Lee Joong-Bok
Park Seung-Yong
Choi In-Soo
Lee Sang-Won
Song Chang-Seon
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Abstract
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C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.
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KEYWORD
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mouthrinse, C31G, gargle, influenza virus
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